An observational study of asymmetry in CMT1A
نویسندگان
چکیده
Contributors RSR contributed to the design of the study, reviewed the data, drafted the manuscript and provided final approval for submission. CL contributed to the design of the study, reviewed the data, performed the statistical analysis, drafted the manuscript and provided final approval for submission. J-PB contributed to the design of the study, reviewed the data, drafted the manuscript and provided final approval for submission.
منابع مشابه
Tripod pinch strength and thumb opposition are the major determinants of manual dexterity in Charcot-Marie-Tooth disease type 1A.
BACKGROUND Clinical features of Charcot-Marie-Tooth disease type 1A (CMT1A) include slowly progressive distal muscle weakness, atrophy and sensory loss. Upper-limb involvement results in reduced manual dexterity interfering with the execution of daily activities. OBJECTIVE To identify which hand function impairments are determinants of manual dexterity in CMT1A. METHODS In a cross-sectional...
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Objectives: Fear of falling (FOF) is a common complication after stroke affecting gait and balance performance in individuals with a history of stroke. The current study aimed at determining the influence of the level of FOF on gait and balance performance after chronic stroke. Methods: A total of 76 persons with chronic stroke (including 41 women), who had no cognitive impairment and could wa...
متن کاملTripod pinch strength and thumb opposition are the major determinants of manual dexterity in CharcoteMarieeTooth disease type 1A
Background Clinical features of CharcoteMarieeTooth disease type 1A (CMT1A) include slowly progressive distal muscle weakness, atrophy and sensory loss. Upper-limb involvement results in reduced manual dexterity interfering with the execution of daily activities. Objective To identify which hand function impairments are determinants of manual dexterity in CMT1A. Methods In a cross-sectional, ob...
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Charcot-Marie-Tooth disease type 1A (CMT1A) is caused by a 1.4 Mb duplication on chromosome 17p11.2, which contains the peripheral myelin protein-22 (PMP22) gene. Increased levels of PMP22 in compact myelin of peripheral nerves have been demonstrated and presumed to cause the phenotype of CMT1A. The objective of the present study was to determine whether an extra copy of the PMP22 gene in CMT1A...
متن کاملAn essential role of MAG in mediating axon-myelin attachment in Charcot-Marie-Tooth 1A disease.
Charcot-Marie-Tooth disease type 1A (CMT1A) is a hereditary demyelinating peripheral neuropathy caused by the duplication of the PMP22 gene. Demyelination precedes the occurrence of clinical symptoms that correlate with axonal degeneration. It was postulated that a disturbed axon-glia interface contributes to altered myelination consequently leading to axonal degeneration. In this study, we exa...
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